#1 Hotel in Iowa, U.S. News & World Report

The Pearl of the Mississippi


As rare as a pearl found in a Mississippi River clam, The Merrill Hotel, Muscatine, A Tribute Portfolio Hotel, is a 4 Diamond, boutique hotel in downtown Muscatine, Iowa, right on the Mississippi River. The Merrill Hotel is a proud member of the International Association of Conference Centers - one of only two IACC certified hotel in the state of Iowa.


"The Merrill Hotel is a beautiful new hotel located right in the heart of downtown Muscatine overlooking the Mississippi River. The hotel is surrounded by a variety of local shops and restaurants in walking distance. There is a beautiful view from just about all the rooms. The staff is very friendly, and the food is amazing. We loved our stay at The Merrill and recommend the hotel to anyone coming into town or just looking for a little get away place to stay!" Recent Guest

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Enjoy Muscatines finest microbrews with tasty treats and souvenirs with this exclusive package with Contrary Brewing Company.

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The only thing better than a getaway is one that includes breakfast. Please your palate with fresh, locally sourced sustainable cuisine.

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We support those on the frontlines of the COVID-19 fight and are proud to take care of those who are taking care of us with a special $69 rate.

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Take advantage of our special wedding offers and start picturing a gorgeous Mark Twain sunset as the backdrop of your wedding day.

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